Tampa Bay Rays vs. Chicago White Sox Picks and Predictions for Wednesday September 10, 2025

By: Dylan Hellebrand Published 09/10/2025, 12:40 AM ET
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On Wednesday, the Tampa Bay Rays (71-72) face off against the Chicago White Sox (55-89) at Rate Field in Chicago, Illinois. This game will be aired on FanDuel Sports Network Sun and Chicago Sports Network. Keep up to date with all the MLB action, with our MLB picks.

Game Information For Rays vs White Sox

  • September 10, 2025, 7:40pm EST, Rate Field, FanDuel Sports Network Sun/Chicago Sports Network
  • 76° cloudy at start time

Chicago White Sox Form & Recent Results

Chicago enters this matchup riding a one-game win streak, having come out victorious in four of their last five games leading up to their series opener against the Tampa Bay Rays. In their most recent contest, a 6-4 win over the Detroit Tigers on Sunday, Lenyn Sosa put on an impressive performance. He went 2-for-4 at the plate, blasted a home run, scored twice, and drove in three runs, helping to secure the win for the White Sox. Sosa has been a major offensive force for Chicago this season. He currently leads the team with 20 home runs, making him the top power hitter in the lineup. Colson Montgomery and Andrew Benintendi are tied for second in home runs on the team, with each player tallying 18 long balls so far. When it comes to driving in runs, Sosa again leads the way, posting a team-best 65 RBIs. He also boasts the highest batting average on the team, hitting .263 for the season. Offensively, the White Sox have been especially potent in recent games, averaging 5.6 runs per game over their last five, highlighting the lineup’s recent hot streak. They’ll aim to maintain this strong offensive output as they begin their series against the Rays on the South Side of Chicago. Overall, the White Sox are averaging 4 runs per game for the season, and their recent surge has given them confidence going into this pivotal matchup.

Tampa Bay Rays Form & Recent Results

Tampa Bay heads into this matchup on the heels of a three-game losing skid and has managed just two wins in their last five games prior to the start of their series against the White Sox. The Rays fell to Cleveland in a close 2-1 contest on Sunday. In that game, Carson Williams provided the team’s only offense, going 1-for-3 at the plate with a solo home run, which accounted for both his RBI and Tampa Bay’s lone run. Throughout the season, Junior Caminero has stood out as the Rays’ power hitter, leading the team with 41 home runs. Brandon Lowe has also been a key contributor, ranking second on the team with 28 home runs this year. Caminero not only leads Tampa Bay in homers but also paces the club in RBIs, having driven in 103 runs so far. Meanwhile, Yandy Diaz has been the most consistent hitter for average, boasting a .292 batting average to top the roster. On the mound, Tampa Bay’s pitching staff has kept games competitive, allowing an average of just 3.6 runs per game over their last five. However, the team’s offense has sputtered recently, an issue they’ll need to address as they try to keep pace with a surging White Sox lineup. Overall, the Rays are averaging 4.5 runs scored per game this season.

Key Players For Rays and White Sox

  • Tampa Bay’s Ryan Pepiot on the road: 4-6, 4.20 ERA, 68 K
  • Chicago’s Lenyn Sosa at home: .285, 9 HR, 37  RBI, .313 OBP

White Sox vs Rays Picks and Prediction

The White Sox seem to have found their rhythm at the plate recently, putting up stronger offensive performances and building momentum. They'll attempt to keep that energy going as they host the Rays. On the other hand, Tampa Bay has struggled throughout the season and is scrambling to climb back to an even .500 record. With their chances of making the playoffs growing slimmer by the day, every game is becoming crucial for the Rays as they fight to keep their postseason hopes alive. Final Score Prediction, Tampa Bay Rays win 5-4.

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