Washington Nationals vs Chicago White Sox Picks and Predictions for Friday April 24 2026

By: Kim Smith Published 04/24/2026, 12:40 AM ET
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The Washington Nationals travel to face the Chicago White Sox at Rate Field in Chicago, Illinois, on Friday, April 24, 2026, with first pitch scheduled for 7:40 PM and coverage available on MLB.TV. The betting odds list Chicago as a -126 favorite on the moneyline, while Washington comes in at +104, with the total set at 9 runs. The Nationals are listed at -1.5 (+156) on the run line, while the White Sox are +1.5 (-190). This matchup features two teams with similar records trying to gain momentum, and readers are encouraged to check out free MLB picksΒ for additional daily insights.

Starting Pitchers Take the Spotlight

Washington will start Miles Mikolas, who enters with a 0-3 record, a 9.15 ERA, and a 1.98 WHIP over 19.2 innings. He has allowed 29 hits while striking out 15 batters and issuing 10 walks, giving up six home runs. Chicago counters with Erick Fedde, who comes in with a 0-3 record, a 3.92 ERA, and a 1.11 WHIP across 20.2 innings. Fedde has allowed 16 hits, struck out 15, walked 7, and surrendered three home runs.

Washington Searching for Stability Despite Offensive Output

The Nationals enter this contest with an 11-15 overall record and an impressive 8-5 mark on the road. Over their last five games, Washington has recently lost to Atlanta three times while also recently winning over Atlanta once and San Francisco once. This stretch reflects a team that has shown flashes of competitiveness but has struggled to consistently close out games.

Washington is hitting .255 as a team with 142 runs scored on 224 hits, including 30 home runs. They have posted a .334 on-base percentage and a .411 slugging percentage. On the pitching side, the Nationals have recorded a 5.65 ERA with a 1.52 WHIP, allowing opponents to hit .267 while striking out 185 batters and issuing 104 walks.

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A major concern for Washington is its pitching performance, as shown by the 5.65 ERA and .267 opponent batting average. These numbers indicate difficulty in limiting opposing offenses, even with a strong run-scoring output.

Chicago Looking to Capitalize at Home

The White Sox come into this matchup with a 10-15 overall record and a 3-6 mark at home. In their last five games, Chicago has recently won over Arizona twice while also recently losing to Arizona once and Oakland once. This recent stretch highlights a team that has shown some offensive capability but remains inconsistent.

Chicago is hitting .222 with 100 runs scored on 176 hits, including 31 home runs. They hold a .315 on-base percentage and a .387 slugging percentage. On the pitching side, the White Sox carry a 5.13 ERA and a 1.50 WHIP, allowing opponents to hit .252 while striking out 180 batters and issuing 116 walks.

A notable strength for Chicago is its power production, as reflected by the 31 home runs. Despite a lower batting average, this ability to generate runs through power gives them an edge in certain matchups.

Washington Nationals vs Chicago White Sox Picks and Prediction

Washington Nationals vs Chicago White Sox Pick

Pick: Chicago White Sox Moneyline

Chicago is the preferred side in this matchup based on the pitching comparison and power advantage. Fedde enters with a significantly lower ERA and WHIP compared to Mikolas, which gives the White Sox an edge on the mound. While both teams have struggled with overall consistency, Chicago’s ability to hit for power combined with Washington’s higher ERA makes the White Sox the stronger option.

Washington Nationals vs Chicago White Sox Total Pick

Pick: Over 9

I would lean toward the over in this matchup because both teams have shown vulnerabilities on the mound. Washington carries a 5.65 ERA, while Chicago sits at 5.13, and both staffs allow relatively high opponent batting averages. With Washington also producing 142 runs and Chicago hitting 31 home runs, this game has the potential to become a higher-scoring contest.

Final Score Prediction: Chicago White Sox 6 – Washington Nationals 5

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