Washington Nationals vs New York Mets Picks and Predictions for Sunday, September 21, 2025

By: David Anicetti Published 09/21/2025, 12:20 AM ET

The Washington Nationals visit the New York Mets on Sunday at Citi Field. 1:40 PM ET on MLB.TV. Washington has lost five straight, including a 12โ€“6 defeat here on Friday, and sits last in the NL East. New York has taken four of its last five and is second in the division. The Nationals have been eliminated from postseason contention, while New York is clinging to the third and final NL wild card with 8 games remaining. Clear the bases with our MLB predictions.

Washington Nationals Preview

The Nationals are 62โ€“92 and 31โ€“45 on the road. James Wood leads the offense with 27 home runs, 89 RBI, and a .349 on-base rate. CJ Abrams has a team-best .264 batting average and 145 hits, while Luis Garcia Jr. and Josh Bell add power but have been less consistent. Washington has scored 653 runs on the year with a .243 average and just 144 home runs.

Jake Irvin starts with an 8โ€“13 record and a 5.76 ERA across 168.2 innings. Irvin has allowed 35 home runs, which has been a problem against stronger lineups. Washingtonโ€™s pitching staff carries a 5.37 ERA and a 1.44 WHIP, showing how much the team has struggled to keep runners off base. The Nationals struggle playing during the day, with a record of 24-43..

New York Mets Preview

The Mets are 80โ€“74 overall and a strong 49โ€“30 at Citi Field. Juan Soto has been the big bat with 42 home runs, 103 RBI, and a .397 on-base percentage. Pete Alonso has added 37 home runs and 122 RBI, while Francisco Lindor has 27 homers and 164 hits. Together, the three lead an offense with 734 runs and 214 home runs, hitting .250 as a team.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers

Subscribe Now

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Picks And Parlays may use third-party services to process my data.

Clay Holmes gets the ball on Sunday. Holmes is 11โ€“8 with a 3.77 ERA and 124 strikeouts in 155.0 innings. He has limited damage with only 14 home runs allowed. New Yorkโ€™s staff ERA is 4.01, and recent results have been strong, including 12 runs scored against Washington on Friday. The Metsโ€™ form at home and recent push in the NL East strengthen their position in this game and for reaching the playoffs.

Washington Nationals vs New York Mets Prediction

This game sets up well for the Mets. Washingtonโ€™s pitching has not kept the ball in the park, while New Yorkโ€™s bats are heating up. With Holmes providing steadier innings than Irvin, the Mets should control this matchup. Expect New Yorkโ€™s offense to go ahead early and the bullpen to hold the lead.

Never Tried Picks and Parlays? Now Is Your Chance

  • Get your first daily picks package for ONLY $1 using coupon code BUCK
  • If the pick loses, we credit your account with 3 Flex Picks
  • If the pick wins, we still give you 1 Flex Pick on the house
  • Win or lose, you walk away ahead. One dollar. No catch.
BetMGM Sport

Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win

Show Bonus Code
Claim Bonus
Signup Promo Recommended BetMGM Sport Bonus
Min. Deposit $5
Cashable No
FanDuel Sportsbook

New Users โ€“ Bet $5 Get $200 in Bet Reset Tokens for 5 Days

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer FanDuel Sportsbook Bonus
Requirement New Users โ€“ Bet $5 Get $200 in Bet Reset Tokens for 5 Days. (Up to $1,000 Bet Reset Tokens)
Cashable No
DraftKings Sport

New DraftKings Customers: Spend $5+ Get $150 in Bonus Bets *Paid Within 14 Days

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer DraftKings Sport Bonus
Min. Deposit $5
Cashable No
Video: Monday MLB Picks Today | MLB Predictions, Props & Best Bets | Morning Wager 8/3
Monday MLB Picks Today | MLB Predictions, Props & Best Bets | Morning Wager 8/3
Video: Phillies vs Orioles: Chip's Best Bets! | MLB Picks Today
Phillies vs Orioles: Chip's Best Bets! | MLB Picks Today

Best Picks

  • New York Mets -1.5
  • First Five Innings Over
logo

If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (IL). Gambling problem? Call 1-800-GAMBLER (MI/NJ/PA/WV/WY), 1-800-9-WITH-IT (IN), 1-800-522-4700 (CO), 1-800-BETS OFF (IA), 1-888-532-3500 (VA), 1-800-NEXT STEP (AZ), or call/text TN REDLINE 1-800-889-9789 (TN). 21+ (18+ WY). AZ/CO/IL/IN/IA/MI/NJ/PA/TN/VA/WV/WY only. Eligibility restrictions apply. T&C's Apply. Void where prohibited. If you click on a link on this site which takes you to a bookmaker or casino and you subsequently open an account, Pick and Parlays may receive a commission. Bets placed are the responsibility of the bettor.

Copyright ยฉ 2026 Picks and Parlays. All rights reserved.

The sports news and information contained at this site is for entertainment purposes only. Any use of this information in violation of laws whether they are federal, state and/or local is prohibited. Picks and Parlays is the nation's premier resource for sports betting and handicapping information.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers
Special Offer
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Play now Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET (Available in the US) 877-8-HOPENY or text HOPENY (467369) (NY) 1-800-327-5050 (MA), 1-800-BETS-OFF (IA), 1-800-981-0023 (PR). 21+ only. Please Gamble Responsibly. See BetMGM.com for Terms. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. Promotional offers not available in Mississippi, New York, Ontario, or Puerto Rico.