Washington Nationals vs St. Louis Cardinals Picks and Predictions for Sunday, September 20th, 2026
Washington Nationals vs St. Louis Cardinals Game Information
The Washington Nationals will close out their weekend road series Sunday afternoon with a 2:15 PM matchup inside Busch Stadium against the St. Louis Cardinals. Washington is 10 games below .500 and fourth in the National League East standings. St. Louis is also below .500 this season and currently occupies fourth place in the National League Central. For more MLB action, see our MLB Picks.
Washington Nationals Preview
Washington’s lineup has recorded a .247 batting average this year, scoring 787 runs on 1296 hits. The Nationals carry a .323 team OBP and a .426 slugging percentage. James Wood leads Washington with a .266 batting average and a .392 OBP. CJ Abrams has sproducedthe most, leading the Nationals with 30 home runs and 97 RBIs.
St. Louis Cardinals Preview
St. Louis has a .242 team batting average this season after scoring 694 runs on 1257 hits. The Cardinals have recorded a .316 OBP and a .381 slugging percentage. Alec Burleson leads the lineup with a .283 batting average and 111 RBIs. Jordan Walker has delivered a team-high 28 home runs while driving in 100 runs for St. Louis.
Washington Nationals vs St. Louis Cardinals Pitching Matchup
Jake Irvin will start for Washington. Irvin is 2-9 with a 5.51 ERA and a 1.41 WHIP across 96.1 innings. He has recorded 96 strikeouts while surrendering 90 hits, 46 walks, and 17 home runs. Quinn Mathews will take the mound for St. Louis. Mathews enters at 2-3 with a 3.62 ERA and a 1.39 WHIP through 37.1 innings, collecting 36 strikeouts while allowing 36 hits, 16 walks, and 3 home runs.
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Washington Nationals vs St. Louis Cardinals Pick
St. Louis has the more dependable starter and will benefit from playing at home. Irvin has struggled throughout the year, carrying an ERA above 5.50 while allowing 17 home runs in fewer than 100 innings. Mathews has limited power damage and should keep Washington from producing a large early total. Look for the Cardinals to get to Irvin during the middle innings before their bullpen closes out the victory.
- Pick: St. Louis Cardinals
- Secondary: Over
- Lean: Jordan Tucker Over 1.5 Bases
Final Score Prediction: St. Louis Cardinals win 6-3
Game Written Before Completion of the Game on Saturday
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