Cleveland Cavaliers vs Charlotte Hornets Picks and Prediction for Wednesday January 21 2026

By: Eddie Kline Updated 01/21/2026, 02:41 PM ET

Cavaliers Preview

The Wednesday NBA schedule will get underway with a matchup between the Cleveland Cavaliers and the Charlotte Hornets from the Spectrum Center. For other NBA action see our NBA Predictions. The Cavaliers (24-20) are a game above .500 on the road and are tied with Orlando for sixth place in the Eastern Conference standings. On Monday, Cleveland allowed Oklahoma City to shoot a sizzling 56 percent from the field during a 136-104 home loss.

All-Star G Donovan Mitchell led five Cleveland players in double figures with 19 points (1-9 3 PT) and three steals. Jarrett Allen scored 16 points to go along with nine rebounds and three blocks. Jaylon Tyson added 16 points and ten boards for the Cavaliers, who missed 27 of 35 three-point attempts.

Hornets Preview

The Charlotte Hornets won three games on their recent five-game road trip and are looking to snap a nine-year postseason drought. The Hornets (16-27) rank 11th in the league in offensive efficiency and are averaging 116.4 points per contest. On Sunday, Charlotte raced out to a 15-point lead and never looked back during a 110-87 road triumph against an injury-depleted Denver squad.

Charlotte F Brandon Miller knocked down 4-for-9 from long distance and finished with a game-high 23 points. Rookie C Ryan Kalkbrenner contributed 17 points and six rebounds in 23 minutes off the bench. Collin Sexton added 14 points and five assists for the Hornets, who dominated the Nuggets on the glass by a 52-29 margin.

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Cavaliers vs Hornets Pick

Cleveland G Darius Garland suffered a big toe sprain and will miss the next seven-to-ten days. The Cavaliers are looking to bounce back from a lifeless loss and the Hornets will be flat after a long road trip. Take Cleveland to win and cover as a small road favorite. Final Score Prediction, Cleveland Cavaliers win 122-113.

How To Bet This Matchup

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