Cleveland Cavaliers vs Philadelphia 76ers Picks and Prediction for Friday January 16 2026

By: Eddie Kline Updated 01/21/2026, 02:43 PM ET

Cavaliers Preview

In the first game of a Friday night NBA on ESPN doubleheader, the Cleveland Cavaliers will square off against the Philadelphia 76ers in a rematch from the Wells Fargo Center. For other NBA action see our NBA Predictions. The Cavaliers (23-19) have split their first 18 road games and are tied with Orlando for sixth place in the Eastern Conference standings. On Wednesday, Cleveland raced out to a 15-point lead after one quarter and cruised to a 133-107 road victory.

All-Star G Donovan Mitchell poured in a game-high 35 points (11-22 FG) to go along with nine assists and seven rebounds. Cleveland G Darius Garland chipped in 20 points (8-13 FG) and seven assists. Evan Mobley added 17 points, 13 rebounds, and six assists for the Cavaliers.

76ers Preview

The Philadelphia 76ers have won six of their last ten games and are sitting in fifth place in the Eastern Conference standings. The 76ers (22-17) rank ninth in the league in defensive efficiency and are allowing 115.6 points per contest. During Wednesday’s home loss, Philadelphia missed 29 of 42 three-point attempts and shot 40 percent overall.

Joel Embiid led Philadelphia with 20 points on 7-for-14 shooting and committed six turnovers. Paul George added 17 points (7-14 FG), four rebounds, and four assists. All-Star G Tyrese Maxey scored 14 points (5-16 FG) and finished with a minus 22 rating for the 76ers, who fell to 10-10 at home.

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Cavaliers vs 76ers Pick

Cleveland G Darius Garland exited Wednesday’s game with a foot injury and is listed as day-to-day. The Cavaliers bounced back from an ugly loss against Utah and will likely be flat in this spot. Take the 76ers to earn a split with a home victory. Final Score Prediction, Philadelphia 76ers win 124-113.

How To Bet This Matchup

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