Cleveland Cavaliers vs San Antonio Spurs Picks and Predictions for Monday December 29 2025

By: Kyle Kargel Published 12/29/2025, 09:01 AM ET
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Cleveland Cavaliers vs San Antonio Spurs picks highlight Monday night’s NBA slate, and this matchup sets up as a classic buy-low spot for bettors looking to capitalize on market overreaction. With recent form, injuries, and point spread movement all colliding, this game offers real value for sharp NBA bettors searching for winning NBA picks.

TLDR: Quick Picks and Prediction

  • Spread: San Antonio -3
  • Total: Under 241.5
  • Projected Final Score: Spurs 121, Cavaliers 115

Odds and Line Movement

Current Odds

Team Spread
Cleveland +3 (-110)
San Antonio -3 (-110)

Line Movement - Spread

Date Cleveland San Antonio
12/29 +3 (-110) -3 (-110)
12/28 +5.5 (-115) -5.5 (-105)

Line Movement - Total

Date Over Under
12/29 241.5 (-110) 241.5 (-110)
12/28 242.5 (-110) 242.5 (-110)

Key Matchups and Game Preview

Cleveland has dominated this series recently, winning six straight meetings against San Antonio, including a 13-point home victory just three weeks ago. However, those results came without Victor Wembanyama on the floor. The Spurs’ star center has missed the last three matchups with Cleveland, and his presence alone changes the matchup dynamic on both ends of the court.

Both teams enter this contest on equal rest after playing Saturday and both are coming off frustrating losses. San Antonio stumbled at home as a 13-point favorite against Utah, while Cleveland has dropped consecutive road games against the Knicks and Rockets. Those recent results have driven line movement toward the Spurs, especially given Cleveland’s ongoing struggles away from home.

From a betting standpoint, Cleveland’s season-long profile is difficult to ignore. The Cavaliers are 9-24 against the spread overall and just 4-10 ATS on the road. San Antonio’s offense stalled badly without De’Aaron Fox last game, but if Fox is active, the Spurs should be able to dictate pace and attack Cleveland’s perimeter defense more effectively.

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  • Cleveland is 9-24 ATS this season.
  • The Cavaliers are 4-10 ATS on the road.
  • San Antonio has won six straight meetings against Cleveland.
  • Recent meetings have been slower-paced without Wembanyama.

Key Injuries and Things To Know (CLE vs SA)

  • Larry Nance Jr. remains out for Cleveland.
  • Max Strus remains sidelined for the Cavaliers.
  • De’Aaron Fox is questionable for San Antonio.
  • Victor Wembanyama is expected to play after missing recent meetings.

Side and Over and Under Picks

  • Side Pick: San Antonio -3
  • Total Pick: Under 241.5

Final Score Prediction

If Fox is available, San Antonio should look far more organized offensively than it did against Utah. Cleveland’s road issues and poor ATS profile make it hard to trust them catching a short number, especially against a motivated Spurs team at home.

Final Score: Spurs 121, Cavaliers 115

How to Wager On Cleveland vs San Antonio

This matchup is best approached by monitoring injury news, particularly Fox’s status, before locking in a side. Bettors looking for value should compare prices using the latest sportsbook promos and shop lines across the best betting sites.

Those seeking additional value can also explore options like the Betmgm bonus code, Novig promo code, and free betting apps. Alternative bettors may want to check out the Thrillz promo code or current Sweepstakes casino promos before placing their wagers.

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