Indiana Pacers vs Cleveland Cavaliers Picks and Prediction for Friday November 21 2025

By: Eddie Kline Published 11/21/2025, 12:40 AM ET

Pacers Preview

The Friday night NBA schedule will get started with a matchup between the Indiana Pacers and the Cleveland Cavaliers from Rocket Arena. For other NBA action see our NBA Predictions. The Pacers (2-13) are winless through their first eight road games and rank near the bottom of the league in offensive efficiency. On Wednesday, Indiana built a 16-point halftime advantage and cruised to a 127-118 home victory versus Charlotte.

Benedict Mathurin led a balanced Indiana scoring attack with 24 points (7-13 FG) and 12 rebounds. All-Star F Pascal Siakam chipped in 22 points (9-17 FG) and seven assists. Jay Huff added 20 points in 27 minutes off the bench for the Pacers, who shot 54 percent from the field. Betting on sports and on the Pacers is easy, but even easier if you use the best sportsbooks.

Cavaliers Preview

The Cleveland Cavaliers have won six of their first nine home games and are tied with New York for third place in the Eastern Conference standings. The Cavaliers (10-6) rank eighth in the league in defensive efficiency and are allowing 116.1 points per contest. On Wednesday, Cleveland trailed by 14 points after one quarter and never recovered during a 114-104 home loss versus Houston.

Cleveland F De’Andre Hunter knocked down 5-for-8 from long distance and finished with a team-high 25 points. All-Star G Donovan Mitchell scored 21 points (8-17 FG) and posted a team-worst minus 18 rating. Evan Mobley added 18 points and six boards for the Cavaliers, who were outrebounded by a 51-39 margin. Make sure you know about how the fans are looking on prediction markets for the Cavaliers with the Novig promo code.

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Pacers vs Cavaliers Pick

Cleveland G Darius Garland is dealing with a toe injury and could be cleared to play as soon as Friday. The Pacers have really struggled to score and have been inefficient on the defensive side of the ball as well. This one could get ugly. Take the Cavaliers to win and cover at home. Final Score Prediction, Cleveland Cavaliers win 129-108. Make sure when you place your bet on Pacers vs Cavaliers you are using the BetMGM bonus code.

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