Philadelphia 76ers vs Detroit Pistons Picks and Prediction for Wednesday November 4 2026
In the first game of a Wednesday night NBA on ESPN doubleheader, the Philadelphia 76ers will visit the Detroit Pistons. Tipoff is scheduled for Wednesday November 4, 2026 at 7:00 pm EST and the scene will be a raucous Little Caesars Arena. The Pistons have been installed as a 2.5 point home favorite and the total is 217.5. For other NBA action see our NBA Predictions.
Philadelphia off to a strong start
The Philadelphia 76ers have advanced to the second round of the playoffs in six of the previous nine years and are in search of their first championship since 1983. The 76ers (5-1) are riding a four-game winning streak and are sitting atop the Eastern Conference standings. On Monday, Philadelphia led for 91 percent of the time during an easy 126-107 home victory versus Chicago.
All-Star G Tyrese Maxey tallied a game-high 26 points (10-15 FG), 11 assists, and four rebounds. All-Star G Jaylen Brown contributed 25 points on 9-for-15 shooting to go along with 11 rebounds and five assists. Four-time MVP LeBron James added 15 points, nine assists, and seven boards for the 76ers.
Despite their early season success, the 76ers rank in the middle of the pack in offensive efficiency and are averaging 110.9 points per contest. During Monday’s victory, Philadelphia assisted on 36 of 48 made field goals and shot 53 percent overall. The 76ers outrebounded the Bulls by a 47-42 margin and led by as many as 22 points.
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Detroit still elite on defense
The Detroit Pistons won 31 of 40 home games a season ago and finished four games ahead of Boston for the top spot in the Eastern Conference. The Pistons (6-1) have won their first two home games and are a half-game behind Philadelphia for first place. On Monday, Detroit outscored Charlotte by 22 points in the second half to run away with a 124-91 road triumph.
All-Star G Cade Cunningham poured in a game-high 33 points on 13-for-20 shooting and dished out seven assists. Sharp-shooter Duncan Robinson nailed 6-for-9 from long distance and finished with 24 points. Ausar Thompson added 14 points (5-7 FG) and six rebounds for the Pistons.
Detroit has made their mark as a physical defensive team and are currently second in the NBA in defensive efficiency. During Monday’s victory, the Pistons forced 27 turnovers and converted them into 37 points. Detroit connected on 18-for-37 from behind the arc and shot a sizzling 57 percent overall.
Philadelphia 76ers vs Detroit Pistons Picks and Prediction
Pick: Detroit Pistons -2.5
Detroit C Jalen Duren (hamstring) and G Isaiah Joe (hip) have been officially ruled out of this contest. The Pistons have reeled off six consecutive wins against the 76ers by an average of 14 points. Detroit is the better offensive team and holds the edge on the glass. Take the Pistons to win and cover at home.
Pick: Under 217.5
Philadelphia ranks 12th in the league in pace and Detroit plays at the fifth slowest tempo. Both teams are in the top three in defensive efficiency and the 76ers are averaging 103 points in their last six meetings against the Pistons. Philadelphia owns a 2-6 O/U mark and their games are staying under the total by an average of nearly 15 points. Take the under.
Final Score Prediction: Detroit Pistons win 110-99
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