San Antonio Spurs vs Los Angeles Lakers Picks and Prediction for Wednesday December 10 2025

By: Eddie Kline Published 12/10/2025, 12:45 AM ET

Spurs Preview

A spot in the NBA Cup Semifinals will be up for grabs on Wednesday night, when the San Antonio Spurs battle the Los Angeles Lakers from Crypto.com Arena. For other NBA action see our NBA Predictions. The Spurs (16-7) have won seven of their last ten games and are a game out of second place in the Western Conference standings. On Monday, San Antonio connected on 17-for-36 from the three-point line during a 135-132 road victory against New Orleans.

Veteran F Harrison Barnes led seven San Antonio players in double figures with 24 points on 9-for-15 shooting. Rookie G Dylan Harper chipped in 22 points and six assists off the bench. Stephon Castle added 18 points, five rebounds, and five assists for the Spurs.

Lakers Preview

The Los Angeles Lakers have won seven of their first ten home games and are tied with Denver for second place in the Western Conference standings. The Lakers (17-6) rank sixth in the league in offensive efficiency and are averaging 118.3 points per contest. On Sunday, Los Angeles held Philadelphia to 35 percent from the field during a 112-108 road victory.

All-Star F Luka Doncic tallied a game-high 31 points (9-24 FG), 15 rebounds, and 11 assists. Four-time NBA MVP LeBron James contributed 29 points, seven rebounds, and six assists. Rui Hachimura added 17 points and six boards for the Lakers.

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Spurs vs Lakers Pick

San Antonio F/C Victor Wembanyama has been sidelined since November 14th with a left calf strain and will not play in this game. These two teams rank in the top seven of their league in offensive efficiency, so the over is worth a look. The stronger play is on the Lakers to win and cover at home. Final Score Prediction, Los Angeles Lakers win 126-115. Make sure you know about how the fans are looking on prediction markets for the Spurs with the Thrillz promo code. Make the most of your bets on the Lakers by using the sportsbook promos. Make sure when you place your Spurs vs Lakers bet you are using the bet365 bonus code.

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