Detroit Red Wings at Buffalo Sabres Picks and Predictions for Wednesday, October 22, 2025
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The Detroit Red Wings visit the Buffalo Sabres at KeyBank Center on Wednesday. Detroit is 5–1–0 (1–0–0 away) and second in the Atlantic Division after a 4–2 home win over Edmonton. Buffalo is 2–4–0 (2–2–0 home) and sixth in the Atlantic Division following a 4–2 road loss to Montreal. Build your bankroll by using our free NHL picks.
Game Information for Red Wings vs Sabres
Day/Date: Wednesday, October 22
Time: 7:30 PM ET
Where: KeyBank Center, Buffalo, NY
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TV/Stream: TNT / HBO Max
Detroit Red Wings Preview
Detroit has opened the season strong, winning five in a row. The Red Wings average 3.33 goals per game and allow 2.33. Dylan Larkin leads the team with 11 points and 5 goals, while Alex DeBrincat has 6 assists. Patrick Kane has 5 points in five games but is listed day-to-day.
The Red Wings’ power play is scoring on 22.2% of its chances, and the penalty kill has been successful 92.3% of the time Detroit is shorthanded. Detroit averages 26.8 shots per game and gives up 25.2. The top defensive pair, led by Moritz Seider, has limited opponents’ clean looks near the crease. Detroit is playing well at both ends with short shifts, quick puck movement, and limiting errors on defense.
Buffalo Sabres Preview
Buffalo has lost three of its last four and is looking for more offense. The Sabres average 2.60 goals per game and allow 2.80. Zach Benson leads with 6 assists, while Jason Zucker has 3 goals. Josh Doan has produced 5 points, including 2 power-play goals.
The Sabres’ power play ranks at 27.8%, and the penalty kill is among the best at 95.7%. Buffalo averages 29.0 shots per game but allows 34.0, often spending extended time in its own end. The Sabres need better play in transition from their centers and more traffic in front of the net to generate scoring chances.
Goaltending Matchup
Detroit: Cam Talbot (3–0–0, 1.78 GAA, .932 SV%); John Gibson (2–1–0, 2.99 GAA, .873 SV%)
Buffalo: Alex Lyon (2–4–0, 2.44 GAA, .924 SV%)
Detroit’s Talbot has been strong in net for the Red Wings. Buffalo’s Lyon has performed well but hasn’t received enough goal support.
Detroit Red Wings at Buffalo Sabres Prediction
Detroit has been more consistent at both ends and continues to control play through strong play in transition, excellent defense in front of goal, and forechecking. Buffalo’s defensive lapses and shots allowed remain concerns. The Red Wings’ relentless pace will carry them to another win. Final Score Prediction: Detroit Red Wings win 3-2.
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